Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP).

Abstract

Effects of serotonergic anxiolytic buspirone on immobilization-induced hyperglycemia were studied in mice. Stress elicited hyperglycemia in mice. Pretreatment with buspirone significantly reduced immobilization-induced hyperglycemia. Buspirone increased serum insulin levels in both non- and stressed mice. The major metabolite of buspirone, 1-(2-pyrimidinyl)piperazine (1-PP) also increased and this further inhibited immobilization-induced hyperglycemia, since 1-PP increased serum insulin levels in both non-stressed and stressed mice, similar to the increases induced by buspirone. These results suggest that buspirone can reduce stress-induced hyperglycemia by facilitating insulin release. Moreover, 1-PP, a metabolite of buspirone may participate in the effects of buspirone. Since 1-PP is an antagonist of alpha(2) receptors, alpha(2) receptors may be related to effects of 1-PP.

• Authors: Yumi Sugimoto, Nozomu Takashima, Toshiko Noma, Jun Yamada
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 28 Issue 4 Pg. 733-5 (Apr 2005) ISSN: 0918-6158 [Print] Japan
• PMID: 15802819 (Publication Type: Journal Article)

Chemical References

• Insulin
• Serotonin 5-HT1 Receptor Agonists
• Serotonin Receptor Agonists
• 1-(2-pyrimidinyl)piperazine
• Buspirone

Topics

• Animals
• Buspirone (analogs & derivatives, pharmacology)
• Hyperglycemia (drug therapy, etiology)
• Insulin (blood)
• Male
• Mice
• Serotonin 5-HT1 Receptor Agonists
• Serotonin Receptor Agonists (pharmacology)
• Stress, Physiological (blood)