[Connubial contact dermatitis to an inhaled corticosteroid].

Abstract

BACKGROUND:

Inhaled corticosteroids are widely used in allergic asthma and rhinitis. They are most often used alone or sometimes in association. Allergic side-effects of inhaled corticosteroids are less frequent than those of topical corticosteroids. We report a case of a connubial dermatitis to a budesonide spray.

OBSERVATION:

A 3-year old boy was treated for asthma by budesonide (Pulmicort) and terbutaline (Bricanyl) aerosols with an inhalation chamber (Babyhaler). From the fourth day of treatment onwards, his mother had swollen and itchy lesions on the face with conjunctivitis several hours after the administration of the corticosteroids using the inhalation chamber. The last eruptions were marked by extensive lesions. The patient reported a worsening of her eruption when she was treated with a desonide cream (Tridesonit). Prick-tests conducted later on confirmed the contact allergy to budesonide and Pulmicort spray. They were also positive for Tridesonit cream and triamcinolone acetonide. Repeated open application tests with a 17-butyrate hydrocortisone cream (Locoid) for three weeks remainded negative.

DISCUSSION:

Our observation is original: allergic contact dermatitis to inhaled corticosteroids is rare, the clinical presentation mimicked angioedema although it was a delayed-type hypersensitivity, hypersensitivity was limited to group B corticosteroids and it was in fact a connubial contact dermatitis.

• Authors: N Raison-Peyron, H-B Co Minh, A Vidal-Mazuy, J-J Guilhou, B Guillot
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 132 Issue 2 Pg. 143-6 (Feb 2005) ISSN: 0151-9638 [Print] France
• Vernacular Title: Eczéma de contact par procuration à un corticoïde inhalé.
• PMID: 15798566 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Bronchodilator Agents
• Budesonide
• Terbutaline

Topics

• Administration, Inhalation
• Angioedema (diagnosis)
• Asthma (drug therapy)
• Bronchodilator Agents (administration & dosage, adverse effects, therapeutic use)
• Budesonide (administration & dosage, adverse effects, therapeutic use)
• Child, Preschool
• Dermatitis, Allergic Contact (diagnosis, etiology)
• Diagnosis, Differential
• Humans
• Male
• Nebulizers and Vaporizers
• Terbutaline (administration & dosage, adverse effects, therapeutic use)