Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: Seven out of 10 patients had maculopapular exanthema, 2/10 erythema multiforme, 1/10 urticaria. We analyzed the composition of T-lymphocyte subsets from the infiltrates at the STI571-induced drug eruption site in eight patients. Unlike other drug eruptions, the increase in the CD8 expression was statistically significant, especially in the dermoepidermal junction and the upper dermis (P < 0.01). The enhanced expression of IL-18 and IL-1beta was observed as well. In contrast, ICAM-1 was either weakly positive or negative. CONCLUSION:
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Authors | Hyun Jeong Park, Hei Sung Kim, Hee Jung Kim, Jun Young Lee, Baik Kee Cho, Ah Won Lee, Do Young Yoon, Dae Ho Cho |
Journal | Journal of dermatological science
(J Dermatol Sci)
Vol. 38
Issue 1
Pg. 9-15
(Apr 2005)
ISSN: 0923-1811 [Print] Netherlands |
PMID | 15795119
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Benzamides
- Interleukin-1
- Interleukin-18
- Piperazines
- Pyrimidines
- Imatinib Mesylate
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Topics |
- Adult
- Anti-Bacterial Agents
(adverse effects)
- Benzamides
- Case-Control Studies
- Child
- Drug Eruptions
(metabolism, pathology)
- Female
- Humans
- Imatinib Mesylate
- Immunohistochemistry
- Immunophenotyping
- Interleukin-1
(metabolism)
- Interleukin-18
(metabolism)
- Male
- Middle Aged
- Piperazines
- Pyrimidines
(adverse effects)
- Skin
(metabolism, pathology)
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