Abstract | PURPOSE: METHODS: In rats, exposure to emetic stimuli such as cisplatin causes significant kaolin intake, a phenomenon called pica. We therefore measured cisplatin-induced kaolin intake as an indicator of the emetic response. Rats were pretreated with vehicle, AGBE (dose range 50-150 mg/kg, IP) or ginsenoside Re (2 and 5 mg/kg, IP). Rats were treated with cisplatin (3 mg/kg, IP) 30 min later. Kaolin intake, food intake, and body weight were measured every 24 h for 120 h. Additionally, the free radical scavenging activity of AGBE was measured in vitro using ESR spectroscopy. RESULTS: A significant dose-response relationship was observed between increasing doses of pretreatment with AGBE and reduction in cisplatin-induced pica. Kaolin intake was maximally attenuated by AGBE at a dose of 100 mg/kg. Food intake also improved significantly at this dose (P<0.05). Pretreatment with ginsenoside Re (5 mg/kg) also decreased kaolin intake (P<0.05). In vitro studies demonstrated a concentration-response relationship between AGBE and its ability to scavenge superoxide and hydroxyl radicals. CONCLUSION: Pretreatment with AGBE and its major constituent, Re, attenuated cisplatin-induced pica, and demonstrated potential for the treatment of chemotherapy-induced nausea and vomiting. Significant recovery of food intake further strengthens the conclusion that AGBE may exert an antinausea/ antiemetic effect.
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Authors | Sangeeta Mehendale, Han Aung, Anbao Wang, Jun-Jie Yin, Chong-Zhi Wang, Jing-Tian Xie, Chun-Su Yuan |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 56
Issue 1
Pg. 63-9
(Jul 2005)
ISSN: 0344-5704 [Print] Germany |
PMID | 15791456
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antidiarrheals
- Antineoplastic Agents
- Antioxidants
- Ginsenosides
- Plant Extracts
- Kaolin
- ginsenoside Re
- Cisplatin
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Topics |
- Animals
- Antidiarrheals
(administration & dosage)
- Antineoplastic Agents
(adverse effects)
- Antioxidants
(pharmacology)
- Cisplatin
(adverse effects)
- Disease Models, Animal
- Ginsenosides
(pharmacology)
- Kaolin
(administration & dosage)
- Male
- Oxidative Stress
- Panax
(chemistry)
- Pica
- Plant Extracts
(pharmacology)
- Rats
- Rats, Wistar
- Vomiting
(chemically induced, prevention & control)
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