[High-dose radiation-induced meningioma following prophylactic cranial irradiation for acute lymphoblastic leukaemia].

Abstract

A 12 year-old girl was treated with prophylatic cranial irradiation for acute lymphoblastic leukaemia (ALL). At the age of 39, she was admitted to our hospital for status epilepticus. Computed tomography demonstrated two, enhancing bilateral sided intracranial tumors. After surgery, this patient presented meningiomas which histologically, were of the meningothelial type. The high cure rate in childhood ALL, attributable to aggressive chemotherapy and prophylatic cranial irradiation, is capable of inducing secondary brain tumor. Twelve cases of high-dose radiation-induced meningioma following ALL are also reviewed.

• Authors: Ryosuke Matsuda, Yuji Nikaido, Tomonori Yamada, Hideaki Mishima, Ryo Tamaki
• Journal: No shinkei geka. Neurological surgery (No Shinkei Geka) Vol. 33 Issue 3 Pg. 277-80 (Mar 2005) ISSN: 0301-2603 [Print] Japan
• PMID: 15773318 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Topics

• Adult
• Central Nervous System Neoplasms (prevention & control)
• Cranial Irradiation (adverse effects)
• Female
• Humans
• Meningeal Neoplasms (etiology, surgery)
• Meningioma (etiology, surgery)
• Neoplasms, Second Primary (etiology, surgery)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (radiotherapy)
• Radiotherapy Dosage