Evaluation of extended-release diltiazem once daily for cats with hypertrophic cardiomyopathy.

Abstract

Serum diltiazem concentrations were evaluated following either 30 mg or 60 mg of an extended-release diltiazem administered orally once daily to 13 cats. Sequential blood samples were obtained over 24 hours. Both dosages usually resulted in elevated serum concentrations of >200 ng/mL at 6, 12, 18, and 24 hours. The 30-mg dosage was sometimes associated with low serum concentrations of <50 ng/mL at 18 and 24 hours. The 60-mg dosage (9.3 to 14.8 mg/kg) was associated with lethargy, gastrointestinal disturbances, and weight loss in nine (36%) of 25 client-owned cats. Gastrointestinal disturbances were recognized within 1 week, and weight loss was detected after 2 to 6 months of treatment.

• Authors: Michelle Wall, Clay A Calvert, Sherry L Sanderson, Andrea Leonhardt, Corrie Barker, Tiffany K Fallaw
• Journal: Journal of the American Animal Hospital Association (J Am Anim Hosp Assoc) 2005 Mar-Apr Vol. 41 Issue 2 Pg. 98-103 ISSN: 1547-3317 [Electronic] United States
• PMID: 15767652 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cardiovascular Agents
• Diltiazem

Topics

• Animals
• Cardiomyopathy, Hypertrophic (blood, drug therapy, veterinary)
• Cardiovascular Agents (adverse effects, blood, therapeutic use)
• Cat Diseases (blood, drug therapy)
• Cats
• Diltiazem (adverse effects, blood, therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Male
• Treatment Outcome