MATERIAL AND METHODS: A total of 273 BPH patients with PSA >10 ng/ml and prior negative PZ biopsy underwent an extended biopsy protocol. In patients with a TZ volume <25 cm(3), four TZ biopsies were taken (two cores per side from the apex and base). In patients with a TZ volume > or =25 cm(3) (n=183), six TZ biopsies were taken (three cores per side from the apex, middle and base). Overall, 215 patients were subjected to either transurethral resection of the prostate (n=162) or open enucleation of the
adenoma (n=53).
RESULTS: The extended biopsy revealed
prostate cancers in 21.2% of cases (58/273). The
zonal distribution of the positive cores was as follow: PZ
cancers only in 67.2% of cases (39/58), TZ
cancers only in 13.8% (8/58) and PZ+TZ
cancers in 19% (11/58). Overall, 73.6% (14/19) and 36.8% (7/19) of TZ
cancers were detected at the apex and middle of the TZ, respectively, while no TZ
cancers at all were detected at the
base (p=0.00015). The incidence of
carcinoma on definitive pathology was 5.6% (12/215). Consequently, TZ biopsy detected only 61.3% (19/31) of TZ
cancers. The incidence of pure TZ
cancers was 7.3%. On the chi(2) test, patient age, serum PSA, transrectal ultrasonography findings and PSA density did not correlate significantly with the detection rate of TZ
cancer. Prostate volume (p=0.023), TZ volume (p=0.027) and PSA/TZ density (p=0.007) were predictive of TZ
cancers.
CONCLUSIONS: Although TZ biopsy was the sole site of
cancer in only 2.9% of cases (8/273), it improved the
cancer detection rate by 14% in this selected group of patients. The majority (74%) of TZ
cancers were detected at the apex site. TZ biopsy has a low sensitivity (61%).