Abstract | BACKGROUND: OBJECTIVE: To outline the basic principles of Multiattribute Decision Making (MADM) and describe how one such method-TOPSIS (Technique for Order Preference by Similarity to the Ideal Solution)-can be applied to evaluate the currently available triptans. METHODS: In an example application, summary data from a recent meta-analysis of 53 published and unpublished placebo-controlled trials of the oral triptans were combined in TOPSIS models with computer-generated attribute importance weights representing the entire range of possible values, That is, the relative performance of the triptans was explored across all logically possible combinations of relative importance of the treatment attributes available from the meta-analysis, and uncertainty was assessed based on the confidence intervals from the meta-analysis. RESULTS: CONCLUSION:
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Authors | M D Ferrari, P J Goadsby, R B Lipton, D W Dodick, F M Cutrer, D McCrory, P Williams |
Journal | Journal of neurology
(J Neurol)
Vol. 252
Issue 9
Pg. 1026-32
(Sep 2005)
ISSN: 0340-5354 [Print] Germany |
PMID | 15761676
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Clinical Trials as Topic
- Decision Support Techniques
- Humans
- Migraine Disorders
(drug therapy)
- Tryptamines
(therapeutic use)
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