Management of excessive tearing as a side effect of docetaxel.

Abstract

Docetaxel is a highly effective chemotherapeutic agent for metastatic or locally advanced breast cancer as well as other malignancies. One of the side effects of weekly administration of docetaxel is epiphora (excessive tearing) caused by canalicular stenosis and nasolacrimal duct obstruction. This article summarizes experience with epiphora and canalicular stenosis as a side effect of docetaxel and provides specific recommendations for management of this side effect.

• Authors: Bita Esmaeli
• Journal: Clinical breast cancer (Clin Breast Cancer) Vol. 5 Issue 6 Pg. 455-7 (Feb 2005) ISSN: 1526-8209 [Print] United States
• PMID: 15748466 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents, Phytogenic
• Taxoids
• Docetaxel

Topics

• Antineoplastic Agents, Phytogenic (adverse effects, therapeutic use)
• Breast Neoplasms (drug therapy)
• Conjunctivitis (chemically induced, therapy)
• Constriction, Pathologic
• Docetaxel
• Female
• Humans
• Lacrimal Apparatus Diseases (chemically induced, therapy)
• Taxoids (adverse effects, therapeutic use)