Abstract | PURPOSE: METHODS: In the Swedish CHARGE study, 31 patients met the inclusion criteria (3+ or 4 of the common characteristics of the CHARGE syndrome). The same team of investigators also evaluated 20 Swedish patients with Goldenhar syndrome. In the Brazilian Möbius study, 28 children with a diagnosis of Möbius sequence were studied; some children had a history of exposure during their mother's pregnancy to the abortifacient drug misoprostol in an unsuccessful abortion attempt. RESULTS: In the CHARGE study, five patients had the more severe autism disorder and five had autistic-like condition. In the Goldenhar study, two had autism disorder and one had autistic-like condition. In the Brazilian Möbius study, the systemic findings of the misoprostol-exposed and misoprostol-unexposed patients were almost undistinguishable, and ASD was present in both groups ( autism disorder in five and autistic-like condition in three). CONCLUSION:
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Authors | Marilyn T Miller, Kerstin Strömland, Liana Ventura, Maria Johansson, Jose M Bandim, Christopher Gillberg |
Journal | Transactions of the American Ophthalmological Society
(Trans Am Ophthalmol Soc)
Vol. 102
Pg. 107-20; discussion 120-1
( 2004)
ISSN: 0065-9533 [Print] United States |
PMID | 15747750
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Teratogens
- Misoprostol
- Thalidomide
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Topics |
- Abnormalities, Drug-Induced
- Abnormalities, Multiple
- Adolescent
- Autistic Disorder
(complications, psychology)
- Child
- Child, Preschool
- Eye Abnormalities
(complications)
- Female
- Goldenhar Syndrome
(complications)
- Humans
- Male
- Misoprostol
(adverse effects)
- Mobius Syndrome
(chemically induced, complications)
- Severity of Illness Index
- Teratogens
- Thalidomide
(adverse effects)
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