CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region.

Abstract

CD5+ diffuse large B-cell lymphoma (DLBCL) has recently been identified as a subgroup with different clinical characteristics from CD5- DLBCL and as having a poorer outcome than CD5- DLBCL. Data regarding differences in gene alteration between CD5+ and CD5- DLBCL have accumulated. In this article, we report an analysis of the immunoglobulin heavy-chain gene variable region (VH) gene in 35 cases of CD5+ DLBCL and compare these cases with those with the germline of the VH gene (GL-VH) and those with a somatically hypermutated VH gene (HM-VH). When the CD5+ DLBCL cases were subdivided with a cutoff value of 98% homology in the VH gene, there were 7 cases (20%) of GL-VH and 28 cases (80%) of HM-VH. The proportion of GL-VH cases in CD5+ DLBCL was more than that in CD5 DLBCL. Although we found no significant difference in pretreatment clinical parameters between the GL-VH and HM-VH subgroups, there was a tendency for the GL-VH subgroup to show lower incidences of elevation of lactate dehydrogenase and >1 site of extranodal involvement compared to the HM-VH subgroup. The overall survival curve of the HM-VH subgroup showed a rapid decline followed by a plateau, whereas that of the GL-VH subgroup declined constantly after 5 years, suggesting that GL-VH disease may not be curable by standard therapies. These findings suggest that CD5+ DLBCL with GL-VH shares clinical features with mantle cell lymphoma, the cellular origin of which has been considered to be pre-germinal center B-cells. We therefore propose that analysis of the VH gene is important for predicting the clinical course of CD5+ DLBCL.

• Authors: Naoya Nakamura, Shigeo Nakamura, Motoko Yamaguchi, Ryo Ichinohasama, Tadashi Yoshino, Tetsuo Kuze, Yoshikazu Sasaki, Sachiko Yoshida, Masafumi Abe
• Journal: International journal of hematology (Int J Hematol) Vol. 81 Issue 1 Pg. 58-61 (Jan 2005) ISSN: 0925-5710 [Print] Japan
• PMID: 15717690 (Publication Type: Journal Article)

Chemical References

• CD5 Antigens
• Immunoglobulin Heavy Chains
• Immunoglobulin Variable Region

Topics

• CD5 Antigens (metabolism)
• Germ-Line Mutation
• Germinal Center (pathology)
• Humans
• Immunoglobulin Heavy Chains (genetics)
• Immunoglobulin Variable Region (genetics)
• Lymphoma, B-Cell (genetics, immunology, mortality)
• Lymphoma, Large B-Cell, Diffuse (genetics, immunology, mortality)
• Somatic Hypermutation, Immunoglobulin