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Electrophilic properties of nitroheterocyclic compounds. Potential hypoxic cells radiosensitizers.

Abstract
Investigation of the reduction potential and calculation of the partition coefficient n-octanol/water allow the assessment of the potential suitability of nitropirydine N-oxide compounds in radiotherapy of cancer. Experiments were carried out using cyclic voltammetry with HMDE as working electrode. The electrode reduction of the investigated compounds is quite irreversible and strongly dependent on pH.
AuthorsAnna Zieba-Mizgała, Aniela Puszko, Andrzej Regiec, Janina Kuduk-Jaworska
JournalBioelectrochemistry (Amsterdam, Netherlands) (Bioelectrochemistry) Vol. 65 Issue 2 Pg. 113-9 (Feb 2005) ISSN: 1567-5394 [Print] Netherlands
PMID15713561 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cyclic N-Oxides
  • Radiation-Sensitizing Agents
Topics
  • Cyclic N-Oxides (chemistry, pharmacology, therapeutic use)
  • Electrodes
  • Hypoxia (pathology, radiotherapy)
  • Models, Biological
  • Neoplasms (radiotherapy)
  • Oxidation-Reduction
  • Radiation-Sensitizing Agents (chemistry)
  • Static Electricity

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