Differential chemosensitivity of tumor components in a malignant oligodendroglioma: assessment with diffusion-weighted, perfusion-weighted, and serial volumetric MR imaging.

Abstract

We report the case of malignant oligodendroglioma in a 36-year-old man who underwent diffusion-weighted, perfusion-weighted, and volumetric MR imaging before and after PCV (procarbazine, CCNU, vincristine) chemotherapy. The tumor regions exhibiting a low apparent diffusion coefficient and increased relative cerebral blood volume showed a marked response to chemotherapy and dramatic decrease in volume, whereas the remaining tumor regions showed little change. Diffusion-weighted and perfusion-weighted MR imaging may be helpful in predicting chemosensitivity of glial tumors.

• Authors: Hans Rolf Jäger, Adam D Waldman, Christopher Benton, Nicholas Fox, Jeremy Rees
• Journal: AJNR. American journal of neuroradiology (AJNR Am J Neuroradiol) Vol. 26 Issue 2 Pg. 274-8 (Feb 2005) ISSN: 0195-6108 [Print] United States
• PMID: 15709124 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Diffusion Magnetic Resonance Imaging
• Humans
• Magnetic Resonance Imaging (methods)
• Male
• Oligodendroglioma (drug therapy, pathology)