ACE DD genotype: a predisposing factor for abdominal aortic aneurysm.

Abstract

OBJECTIVE:

To examine the role of polymorphisms in angiotensin converting enzyme (ACE, I/D) and angiotensin II receptor (AT1R, A1166C) in the development of abdominal aortic aneurysm (AAA).

MATERIALS AND METHODS:

We investigated 250 consecutive patients, 217 males and 33 females (median age 72, range 50-83), undergone AAA elective repair and 250 healthy controls, comparable for sex and age. ACE and AT1R polymorphisms were studied by PCR-RFLP analysis. The genotype distribution was in Hardy-Weinberg equilibrium for all polymorphisms.

RESULTS:

The genotype distribution and allele frequency of ACE I/D, but not AT1R A1166C polymorphism were significantly different between patients and controls (ACE I/D: p=0.0002 and p<0.0001, respectively, and AT1R A1166C: p=0.6 and p=0.4, respectively). An association between the ACE DD genotype and the predisposition to AAA was found (OR DD vs. ID+II=1.9 95% CI 1.3-2.9, p<0.0001). Multivariate analysis adjusted for age, sex, traditional vascular risk factors and other atherosclerotic localizations, showed ACE DD genotype to be independently related to the disease (OR DD vs. ID+II=2.4, 95% CI 1.3-4.2 p=0.003).

CONCLUSIONS:

Our findings document that ACE DD genotype represents a susceptibility factor for AAA.

• Authors: C Fatini, G Pratesi, F Sofi, F Gensini, E Sticchi, B Lari, R Pulli, W Dorigo, L Azas, C Pratesi, G F Gensini, R Abbate
• Journal: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (Eur J Vasc Endovasc Surg) Vol. 29 Issue 3 Pg. 227-32 (Mar 2005) ISSN: 1078-5884 [Print] England
• PMID: 15694792 (Publication Type: Journal Article)

Chemical References

• Receptors, Angiotensin
• Peptidyl-Dipeptidase A

Topics

• Aged
• Aged, 80 and over
• Aortic Aneurysm, Abdominal (complications, genetics)
• Causality
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Humans
• Hypertension (complications)
• Male
• Middle Aged
• Peptidyl-Dipeptidase A (genetics)
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length
• Receptors, Angiotensin (genetics)