Multiple sclerosis: long-term remission after a high dose of cyclophosphamide.

Abstract

The objective of this case report is to document the possibility that immunoablative doses of cyclophosphamide may provide a long-term remission of multiple sclerosis (MS). We report the case of a 48-year-old woman with definite MS diagnosed in 1994 who has been in complete remission since a dose of 3800 mg of cyclophosphamide was accidentally given intravenously in early 1997. For 7 years there have been no signs of disease activity on history, physical examination, or on high-quality magnetic resonance imaging (MRI) with appropriate contrast-enhancement methodology. This case includes information on the possibility that less aggressive chemotherapy than that used with stem cell transplantation may be effective in the long-term control of MS.

• Authors: P R M de Bittencourt, M M Gomes-da-Silva
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 111 Issue 3 Pg. 195-8 (Mar 2005) ISSN: 0001-6314 [Print] Denmark
• PMID: 15691289 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclophosphamide

Topics

• Cyclophosphamide (administration & dosage)
• Female
• Humans
• Immunosuppressive Agents (administration & dosage)
• Magnetic Resonance Imaging
• Middle Aged
• Multiple Sclerosis (drug therapy, pathology)
• Remission Induction