Abstract | BACKGROUND: During the recent smallpox vaccination campaigns, ischemic cardiac complications were observed after vaccination. To examine a possible association between the smallpox vaccine and postvaccination ischemic events, we investigated alterations in levels of prothrombotic proteins ( plasminogen activator inhibitor type 1 [PAI-1] and soluble CD40 ligand [sCD40L]) in recently vaccinated individuals. METHODS:
Vaccinia-naive (cohort N; aged 18-32 years) and vaccinia-experienced (cohort E; aged 33-49 years) healthy adults were vaccinated with a 1 : 5 dilution of the Aventis Pasteur smallpox vaccine. Plasma levels of PAI-1 and sCD40L were measured in 30 subjects (cohort N, n=15; cohort E, n=15) at baseline and twice after vaccination (between days 7 and 9 and between days 26 and 30). RESULTS: Baseline mean PAI-1 levels significantly differed between cohorts N and E (P=.04). Within each exposure cohort, mean PAI-1 levels did not significantly change after vaccination. Baseline sCD40L levels did not differ between cohorts N and E. In cohort N, sCD40L levels significantly decreased after vaccination but returned to baseline levels within 1 month. Vaccination did not significantly alter levels of sCD40L in cohort E. CONCLUSIONS: Levels of PAI-1 and sCD40L did not significantly increase after smallpox vaccination. Vaccine-induced alterations in levels of these prothrombotic proteins do not appear to play a role in ischemic events observed after smallpox vaccination.
|
Authors | Julia F Shaklee, Thomas R Talbot, James A S Muldowney 3rd, Douglas E Vaughan, Javed Butler, Frances House, James E Crowe Jr, L Harris Smith, Kathryn M Edwards |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 191
Issue 5
Pg. 724-30
(Mar 01 2005)
ISSN: 0022-1899 [Print] United States |
PMID | 15688286
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Plasminogen Activator Inhibitor 1
- Smallpox Vaccine
- CD40 Ligand
|
Topics |
- Adolescent
- Adult
- CD40 Ligand
(blood)
- Female
- Humans
- Male
- Middle Aged
- Myocardial Ischemia
(blood, chemically induced)
- Plasminogen Activator Inhibitor 1
(blood)
- Smallpox Vaccine
(administration & dosage, adverse effects)
|