Abstract | BACKGROUND: OBJECTIVE: This study compared the effects of a soy-based meal replacement (MR) plan vs an individualized diet plan ( IDP; as recommended by the American Diabetes Association) on weight loss and metabolic profile. DESIGN/SUBJECTS: A total of 104 subjects were randomized prospectively to the two treatments for a total of 12 months. RESULTS: In all, 77 of the 104 subjects completed the study. Percentage weight loss in MR group (4.57+/-0.81%) was significantly greater (P<0.05) than in IDP group (2.25+/-0.72%). Fasting plasma glucose was significantly reduced in MR group (126.4+/-4.9 mg/dl) compared with IDP group (152.5+/-6.6 mg/dl, P<0.0001) at 6 months but not at 12 months. Controlling for baseline levels, hemoglobin Alc level improved by 0.49+/-0.22% for those receiving MR when compared to IDP group (P<0.05). A greater number of subjects in MR group reduced their use of sulfonylureas (P<0.0001) and metformin (P<0.05) as compared to IDP group. High-sensitivity C-reactive protein ( hs-CRP) decreased -26.3% (P = 0.019) in MR group compared to -7.06% (P = 0.338) in IDP group at 6 months. Similar changes were observed at 12 months with MR groups, with hs-CRP decreasing by -25.0% (P = 0.019) compared to -18.7% (P = 0.179) in IDP group. CONCLUSION: This study demonstrates that MR is a viable strategy for weight reduction in diabetic patients, resulting in beneficial changes in measures of glycemic control and reduction of medications.
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Authors | Z Li, K Hong, P Saltsman, S DeShields, M Bellman, G Thames, Y Liu, H-J Wang, R Elashoff, D Heber |
Journal | European journal of clinical nutrition
(Eur J Clin Nutr)
Vol. 59
Issue 3
Pg. 411-8
(Mar 2005)
ISSN: 0954-3007 [Print] England |
PMID | 15674301
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Lipids
- C-Reactive Protein
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Topics |
- Blood Glucose
(metabolism)
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Diabetes Mellitus, Type 2
(blood, diet therapy)
- Female
- Food, Formulated
- Glycated Hemoglobin
(metabolism)
- Humans
- Lipids
(blood)
- Longitudinal Studies
- Male
- Middle Aged
- Obesity
(blood, diet therapy)
- Prospective Studies
- Soy Foods
- Treatment Outcome
- Weight Loss
(physiology)
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