Abstract | OBJECTIVE: The objective of this study was to evaluate the changes in oxygenation of prostate cancer induced by carbogen breathing using blood oxygen level-dependent (BOLD) magnetic resonance image (MRI) with an endorectal coil (eMRI). MATERIALS AND METHODS: In 32 patients with biopsy-proven prostate cancer, endorectal MRI was performed at 1.5 Tesla using the BOLD method. Images were acquired during 4 x 4-minute episodes alternating between room air and carbogen (95% O2/5% CO2) breathing. In each episode, 40 images were acquired (T2*-weighted EPI sequence, 12-14 slices, 3-mm thickness). All patients underwent radical prostatectomy; BOLD-MRI findings were correlated with the histopathologic results. RESULTS: BOLD-MRI could be evaluated in 29 patients, and revealed heterogeneous signal changes of normal prostate and cancer tissue similar to the heterogeneity of prostate tissue in anatomic/pathologic preparation. A significant signal intensity increase (P = 0.004) was found in normal central gland and peripheral zone during carbogen breathing. Signal enhancement in carcinoma was significantly lower (P = 0.004) compared with the contralateral normal side. CONCLUSION: Intrinsic blood-tissue contrast-functional MRI during carbogen breathing may help detect and characterize prostate carcinoma from normal tissue, particularly in small 1-sided carcinomas. This may be useful for identifying candidates for radiotherapy and monitoring noninvasive therapeutic approaches.
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Authors | Till Diergarten, Petros Martirosian, Raimund Kottke, Ulrich Vogel, Arnulf Stenzl, Claus D Claussen, Heinz-Peter Schlemmer |
Journal | Investigative radiology
(Invest Radiol)
Vol. 40
Issue 2
Pg. 102-9
(Feb 2005)
ISSN: 0020-9996 [Print] United States |
PMID | 15654255
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbon Dioxide
- carbogen
- Oxygen
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Topics |
- Aged
- Carbon Dioxide
(administration & dosage)
- Humans
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Oxygen
(administration & dosage)
- Prostatic Neoplasms
(diagnosis, pathology)
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