Intravenous lidocaine suppresses fentanyl-induced coughing: a double-blind, prospective, randomized placebo-controlled study.

Abstract

IV lidocaine is effective in suppressing the cough reflex of tracheal intubation, extubation, bronchography, bronchoscopy, and laryngoscopy. We investigated this effect of lidocaine on fentanyl-induced cough in 502 patients of ASA physical status I and II scheduled for elective surgery. The patients were assigned to 2 equal groups to receive either lidocaine 1.5 mg/kg or placebo (0.9% saline) over 5 s 1 min before the administration of fentanyl 3 mug/kg in a randomized and double-blind fashion. Coughs were classified as coughing and graded as mild (1-2), moderate (3-4), or severe (5 or more). The results of the study suggest that IV lidocaine 1.5 mg/kg, when administered 1 min before fentanyl, is significantly effective in suppressing fentanyl-induced cough compared to placebo (0.9% saline) (218 versus 165 patients) (P < 0.002) but without affecting the severity of cough (P > 0.05).

• Authors: Chandra K Pandey, Mehdi Raza, Rajeev Ranjan, Archana Lakra, Anil Agarwal, Uttam Singh, R B Singh, Prabhat K Singh
• Journal: Anesthesia and analgesia (Anesth Analg) Vol. 99 Issue 6 Pg. 1696-1698 (Dec 2004) ISSN: 0003-2999 [Print] United States
• PMID: 15562056 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics, Opioid
• Anesthetics, Local
• Lidocaine
• Fentanyl

Topics

• Adult
• Analgesics, Opioid (adverse effects)
• Anesthesia, General
• Anesthetics, Local (administration & dosage, pharmacology)
• Cough (chemically induced, prevention & control)
• Double-Blind Method
• Female
• Fentanyl (adverse effects)
• Humans
• Lidocaine (administration & dosage, pharmacology)
• Male
• Middle Aged
• Prospective Studies
• Risk Assessment