Abstract | INTRODUCTION: PATIENTS AND METHODS: A 63-year-old woman was diagnosed as having PSC with solitary HCC. Preoperative liver condition was Child-Pugh grade C. Colonoscopic findings showed an active longitudinal ulcer in the terminal ileum and clinically diagnosed Crohn's disease. The medical treatment was 5'-aminosalicylates. She received a left lobe graft from her daughter. The immunosuppressants were tacrolimus and azathioprine, which was changed to predonisolone because of leukopenia and moderate acute cellular rejection, after which the postoperative course was uneventful. Colonoscopic findings revealed disappearance of the longitudinal ulcer in the terminal ileum at 15 months after LRDLT. There was no evidence of PSC or HCC recurrence. CONCLUSIONS: Generally, PSC with HCC is rare with a poor prognosis; however, LRDLT may be a treatments option although the patient with PSC had a combined HCC. Moreover, aminosalicylates together with the immunosuppressants may be effective for the clinical management of concomitant Crohn's disease.
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Authors | H Oya, Y Sato, S Yamamoto, T Takeishi, T Kobayashi, K Hatakeyama |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 36
Issue 8
Pg. 2297-8
(Oct 2004)
ISSN: 0041-1345 [Print] United States |
PMID | 15561226
(Publication Type: Journal Article)
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Topics |
- Cholangitis, Sclerosing
(complications, surgery)
- Crohn Disease
(complications, surgery)
- Female
- Humans
- Liver Transplantation
(methods)
- Living Donors
- Middle Aged
- Nuclear Family
- Treatment Outcome
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