Abstract | OBJECTIVE: METHODS: We searched Medline, the Cochrane Library and reference lists of retrieved studies to identify randomized trials of >/= 6 months duration with >/= 10 patients in each treatment arm. Data were extracted on study design, patient and treatment characteristics, urinary symptoms, urinary flow, adverse events and repeat treatment for BPH. RESULTS: Six studies were evaluated, involving 540 patients. The mean age (67.8 years), baseline symptom score (19.5), and peak urinary flow (PUF, 8.6 mL/s) did not differ by treatment group. The pooled mean urinary symptom score decreased by 65% with TUMT and 77% with TURP. The weighted mean (95% confidence interval) difference for the symptom score at the follow-up was -1.83 (-3.09 to -0.58) points, favouring TURP. The pooled mean PUF increased by 70% with TUMT and 119% with TURP. The weighted mean difference for the PUF at the follow-up was 5.37 (4.22-6.51) mL/s, favouring TURP. Retrograde ejaculation (57.6% vs 22.2%), transfusions (5.7% vs 0%) and re-treatment for strictures (relative hazard 9.76) were all significantly more common after TURP, but re-treatment for BPH was significantly more common after TUMT (relative hazard 10.0). CONCLUSIONS: TUMT techniques are effective and safe short-term alternatives to TURP for treating BPH. However, TURP provided greater symptom and urinary flow improvements and fewer subsequent BPH treatments than TUMT.
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Authors | Richard M Hoffman, Roderick MacDonald, Manoj Monga, Timothy J Wilt |
Journal | BJU international
(BJU Int)
Vol. 94
Issue 7
Pg. 1031-6
(Nov 2004)
ISSN: 1464-4096 [Print] England |
PMID | 15541122
(Publication Type: Comparative Study, Journal Article, Review, Systematic Review)
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Topics |
- Aged
- Follow-Up Studies
- Humans
- Hyperthermia, Induced
(methods)
- Male
- Microwaves
(therapeutic use)
- Middle Aged
- Prostatectomy
(methods)
- Prostatic Hyperplasia
(therapy)
- Randomized Controlled Trials as Topic
- Transurethral Resection of Prostate
(methods)
|