Influence of rofecoxib on experimental colonic carcinogenesis in rats.

Abstract

AIM:

To investigate the effect of a selective cyclooxigenase-2 (COX-2) inhibitor, rofecoxib, in the prevalence of experimental colon tumors in rats.

EXPERIMENTAL DESIGN:

Experimental study with 35 male Sprague-Dawley rats, divided into four groups: a) control group without experimental manipulation (n = 5); b) pharmacological carcinogenesis with 1-2 dimethylhydrazine dihydrocloride (n = 10); c) pharmacological carcinogenesis and addition of acetylsalicylic acid (AAS) (n = 10); and d) carcinogenesis and addition of rofecoxib (n = 10). Carcinogenesis was induced with 1-2 dimethylhydrazine at a weekly dose of 25 mg/kg for 18 weeks. Colon tumors were isolated at 20 weeks. Antiinflammatory agents were given at a dose of AAS 30 mg/kg and rofecoxib at 3 mg/kg.

RESULTS:

The percentage of colonic tumors was significantly reduced in the rofecoxib group. This result was found for all tumors and for the malignant lesions, adenocarcinomas.

CONCLUSIONS:

Rofecoxib, a selective COX-2 inhibitor, reduced the percentage of drug-induced neoplastic glandular tissue in rats.

• Authors: J F Noguera Aguilar, A Plaza Martínez, I Amengual Antich, J M Morón Canis, C Tortajada Collado, J J Pujol Tugores
• Journal: Revista espanola de enfermedades digestivas (Rev Esp Enferm Dig) Vol. 96 Issue 10 Pg. 678-82; 683-6 (Oct 2004) ISSN: 1130-0108 [Print] Spain
• PMID: 15537374 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors
• Isoenzymes
• Lactones
• Sulfones
• rofecoxib
• Cyclooxygenase 2
• Prostaglandin-Endoperoxide Synthases
• 1,2-Dimethylhydrazine
• Aspirin

Topics

• 1,2-Dimethylhydrazine (toxicity)
• Animals
• Aspirin (therapeutic use)
• Carcinogens (toxicity)
• Colonic Neoplasms (chemically induced, drug therapy)
• Cyclooxygenase 2
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors (therapeutic use)
• Disease Models, Animal
• Drug Therapy, Combination
• Isoenzymes (antagonists & inhibitors)
• Lactones (therapeutic use)
• Male
• Prostaglandin-Endoperoxide Synthases
• Rats
• Rats, Sprague-Dawley
• Sulfones (therapeutic use)