In vivo MRI measurement of blood oxygen saturation in children with congenital heart disease.

Abstract

OBJECTIVE:

The purpose of this prospective study was to measure in vivo blood oxygen saturation (%O2) by MRI in children with congenital heart disease (CHD) using population-based values for T2O (T2 signal decay of fully oxygenated blood) and K (a parameter representing the deoxyhemoglobin effect) and compare the %O2 with direct cardiac catheterization measurements.

BACKGROUND:

MRI can determine %O2 using in vivo measurement of signal decay (T2) and an in vitro calibration curve relating T2 and %O2, based on the equation: 1/T2 = 1/T2O + K(1-%O2/100)2. Recent studies have correlated the T2/%O2 in children with CHD with the adult calibration statistics.

METHODS:

A total of ten children (five male, five female) with single ventricle CHD (median age 4.8 months, range 2 months to 4.4 years) undergoing cardiac catheterization were included in the study. The blood T2 measurements for each patient were performed in a 1.5 T GE CV scanner. The %O2 was then calculated based on the equation using values of T2O determined from individual hematocrits, and a population average value of K derived for children. The %O2 values were compared with direct %O2 measurements from cardiac catheterization.

RESULTS:

The %O2 values by MRI were strongly correlated with direct cardiac catheterization measurements (R = 0.825; P < 0.001).

CONCLUSION:

The study indicates that the noninvasive measurement of %O2 by MRI can accurately measure oxygen saturation in children with complex CHD.

• Authors: Lynne E Nield, Xiu-Ling L Qi, Emanuela R Valsangiacomo, Christopher K Macgowan, Graham A Wright, Lisa K Hornberger, Shi-Joon Yoo
• Journal: Pediatric radiology (Pediatr Radiol) Vol. 35 Issue 2 Pg. 179-85 (Feb 2005) ISSN: 0301-0449 [Print] Germany
• PMID: 15490150 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oxygen

Topics

• Aorta (pathology)
• Cardiac Catheterization
• Child, Preschool
• Female
• Heart Atria (pathology)
• Heart Defects, Congenital (blood, pathology)
• Humans
• Infant
• Magnetic Resonance Imaging
• Male
• Oximetry (methods)
• Oxygen (blood)
• Prospective Studies
• Pulmonary Artery (pathology)
• Vena Cava, Superior (pathology)