Early onset of subclinical atherosclerosis in young persons with type 1 diabetes.

Abstract

OBJECTIVE:

To evaluate the degree of atherosclerosis and its risk factors in adolescents and young adults with type 1 diabetes.

STUDY DESIGN:

We measured carotid artery intima-media thickness (IMT) in 142 subjects with type 1 diabetes (mean [SD] age = 16.0 [2.6] years) and 87 control subjects (18.8 [3.1] years). Fasting lipid and homocysteine levels, degree of glycemic control, blood pressure, and body mass index were measured in persons with diabetes.

RESULTS:

The mean carotid IMT was greater in persons with diabetes ( P = .002). Among subjects with type 1 diabetes, lipid levels were significantly higher in female subjects compared with male subjects. The mean carotid IMT was significantly higher in persons with a diabetic complication (including hypertension, retinopathy, or microalbuminuria). In male subjects but not female subjects, HDL cholesterol and the LDL/HDL ratio were correlated with carotid IMT.

CONCLUSIONS:

Adolescents with type 1 diabetes have increased atherosclerosis compared with control subjects. Risk factors for increased carotid IMT in these younger patients include diabetic complications and HDL cholesterol and the LDL/HDL ratio, which may be sex-specific.

• Authors: Jody S Krantz, Wendy J Mack, Howard N Hodis, Chao-Ran Liu, Ci-Hua Liu, Francine R Kaufman
• Journal: The Journal of pediatrics (J Pediatr) Vol. 145 Issue 4 Pg. 452-7 (Oct 2004) ISSN: 0022-3476 [Print] United States
• PMID: 15480366 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipids
• Homocysteine

Topics

• Adolescent
• Adult
• Arteriosclerosis (blood, diagnostic imaging, etiology)
• Blood Pressure
• Body Mass Index
• Carotid Artery, Common (diagnostic imaging)
• Case-Control Studies
• Child
• Diabetes Mellitus, Type 1 (blood, complications, diagnostic imaging)
• Female
• Homocysteine (blood)
• Humans
• Lipids (blood)
• Male
• Risk Factors
• Severity of Illness Index
• Sex Factors
• Tunica Intima (diagnostic imaging)
• Tunica Media (diagnostic imaging)
• Ultrasonography