Abstract | BACKGROUND: METHODS: We measured the concentrations of hBD-1, hBD-2, and LL-37 in bronchoalveolar lavage fluid of 20 patients (5-34 years) participating in the prospective BEAT-study (bronchoalveolar lavage for the evaluation of anti-inflammatory treatment) using an immuno-dot blot-assay. RESULTS: All three peptides could be detected in lavage fluid of the study population. Increased levels of inflammatory markers in bronchoalveolar lavage fluid were associated with elevated concentrations of LL-37/ hCAP-18 (total cell count, P = 0.006; relative neutrophil count, P = 0.002). Deterioration of lung function, measured by MEF25 (maximal flow rate at 25% of residual forced vital capacity), correlated with decreased hBD-2 (P = 0.026), but increased LL-37/ hCAP-18 concentrations (P = 0.016). CONCLUSIONS:
|
Authors | Christiane I-U Chen, Susanne Schaller-Bals, Karl P Paul, Ulrich Wahn, Robert Bals |
Journal | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
(J Cyst Fibros)
Vol. 3
Issue 1
Pg. 45-50
(Mar 2004)
ISSN: 1569-1993 [Print] Netherlands |
PMID | 15463886
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antimicrobial Cationic Peptides
- Biomarkers
- DEFB1 protein, human
- DEFB4A protein, human
- beta-Defensins
- Cathelicidins
|
Topics |
- Adolescent
- Adult
- Antimicrobial Cationic Peptides
(analysis, metabolism)
- Biomarkers
(analysis)
- Bronchoalveolar Lavage Fluid
(chemistry)
- Child
- Child, Preschool
- Cystic Fibrosis
(diagnosis)
- Female
- Humans
- Male
- Probability
- Prognosis
- Prospective Studies
- Risk Assessment
- Sensitivity and Specificity
- Severity of Illness Index
- Statistics, Nonparametric
- beta-Defensins
(analysis, metabolism)
- Cathelicidins
|