Effects of cytoflavin and neuronol on morphological changes in the brain and survival of rats with ischemic disturbances in cerebral blood flow.

Abstract

Cytoflavin and neuronol produce vasoactive and neuroprotective effects in rats with cerebral ischemia. Vasoactive activity of neuronol was higher than that of cytoflavin. These differences were most pronounced at the level of microcirculation. Test preparations were equally potent in producing the neuroprotective effect. Cytoflavin and neuronol markedly decreased the mortality rate of animals. Over the first 6 h of ischemia the relative effectiveness of cytoflavin was higher than that of neuronol. However, neuronol exceeded cytoflavin in the relative effectiveness during the follow-up period (days 1-21).

• Authors: V V Bul'on, I B Krylova, N R Evdokimova, A L Kovalenko, L E Alekseeva, N S Sapronov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 137 Issue 4 Pg. 411-4 (Apr 2004) ISSN: 0007-4888 [Print] United States
• PMID: 15452617 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Drug Combinations
• Neuronol
• Neuroprotective Agents
• Succinates
• Niacinamide
• Flavin Mononucleotide
• Inosine Diphosphate
• Succinic Acid

Topics

• Animals
• Brain (drug effects, pathology)
• Brain Ischemia (metabolism, pathology, physiopathology)
• Cerebrovascular Circulation
• Drug Combinations
• Flavin Mononucleotide (pharmacology)
• Inosine Diphosphate (pharmacology)
• Male
• Neuroprotective Agents (pharmacology)
• Niacinamide (pharmacology)
• Rats
• Regional Blood Flow
• Reperfusion Injury (pathology, physiopathology, prevention & control)
• Succinates (pharmacology)
• Succinic Acid (pharmacology)
• Survival Rate