[Sirolimus-eluting stents for the treatment of symptomatic extracranial vertebral artery stenoses: early experience and 6-month follow-up].

Abstract

PURPOSE:

To evaluate the clinical and morphological effectiveness of sirolimus-eluting stents in patients with stenoses in the extracranial vertebral artery and to assess the 6-month results.

MATERIALS AND METHODS:

Sirolimus-eluting stents were implanted in 8 stenoses of the extracranial vertebral artery in 7 patients with symptoms of vertebrobasilar insufficiency. Seven stenoses were located at the ostium, and one further cranially in segment V 1. The mean grade diameter of the stenoses was 85.1 % (60.9 % - 98.3 %). Clinical and angiographic follow-up was performed over a period of 6 months in all patients.

RESULTS:

All lesions were successfully stented with a residual stenosis of 20.2 % (0.0 - 38.5 %). Clinically, all patients showed resolution or improvement of the symptoms after stenting. After 6 months, 5 of the 8 stenoses developed intimal hyperplasia with a stenosis grade > 50 %. The mean measured grade of stenosis after 6 months was 56.2 % (0.0 - 94.1 %). Five patients had no clinical symptoms of a vertebrobasilar insufficiency while two had recurrent symptoms.

CONCLUSION:

Sirolimus-eluting stents in the extracranial vertebral artery have a high and unsatisfactory re-stenosis rate after 6 months.

• Authors: H Lugmayr, M Kastner, W Fröhler, S Meindl, R Zisch
• Journal: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (Rofo) Vol. 176 Issue 10 Pg. 1431-5 (Oct 2004) ISSN: 1438-9029 [Print] Germany
• Vernacular Title: Die Behandlung symptomatischer extrakranieller Stenosen der Arteria vertebralis mit sirolimusbeschichteten Stents: erste Erfahrungen und Ergebnisse nach 6 Monaten.
• PMID: 15383974 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Immunosuppressive Agents
• Sirolimus

Topics

• Adult
• Aged
• Angiography
• Anti-Bacterial Agents (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Immunosuppressive Agents (administration & dosage)
• Male
• Middle Aged
• Recurrence
• Sirolimus (administration & dosage)
• Stents
• Time Factors
• Vertebral Artery
• Vertebrobasilar Insufficiency (diagnosis, diagnostic imaging, therapy)