Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.

Abstract

The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis. The elevated expression of these proteins in tumor cells and their post-translational modifications, such as phosphorylation, acetylation and methylation, are discussed and suggested as suitable targets for cancer chemotherapy.

• Authors: Riccardo Sgarra, Alessandra Rustighi, Michela A Tessari, Julie Di Bernardo, Sandro Altamura, Alfredo Fusco, Guidalberto Manfioletti, Vincenzo Giancotti
• Journal: FEBS letters (FEBS Lett) Vol. 574 Issue 1-3 Pg. 1-8 (Sep 10 2004) ISSN: 0014-5793 [Print] England
• PMID: 15358530 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Chromatin
• High Mobility Group Proteins

Topics

• Acetylation
• Amino Acid Sequence
• Apoptosis (physiology)
• Cell Transformation, Neoplastic
• Chromatin (chemistry)
• High Mobility Group Proteins (chemistry, physiology)
• Methylation
• Molecular Sequence Data
• Neoplasms (physiopathology)
• Protein Conformation
• Sequence Homology, Amino Acid