HTLV envelopes and their receptor GLUT1, the ubiquitous glucose transporter: a new vision on HTLV infection?

Abstract

We identified the ubiquitous glucose transporter GLUT1 as a receptor for Deltaretroviruses HTLV-1 and HTLV-2 envelopes (Env), mediating viral binding and entry. Here, we review the context and key observations that led us to this finding: functional modules of HTLV SU are similar to those of Gammaretrovirus Env which use multimembrane-spanning nutrient transporters as receptors; the HTLV Env receptor is an early marker of T lymphocyte activation; and HTLV Env inhibits glucose transport. We review several molecular, viral, cellular and physiological aspects of HTLV infection in relation to the in vivo and in vitro properties of GLUT1. Also, we examine the implications of HTLV-1 Env-GLUT1 interactions and altered glucose transport on the two major HTLV-1-induced diseases, adult T cell leukemia (ATL) and neurodegenerative tropical spastic paraparesis/HTLV-associated myelopathy (TSP/HAM). Complementary to the classical models of disease progression, we propose new schemes that emphasize the potential metabolic alterations caused in different cellular compartments. Finally, we review the potential use of HTLV Env-derived constructs as tools for labeling GLUT1 in vivo and inhibiting GLUT1 transport in tumor cells.

• Authors: Nicolas Manel, Naomi Taylor, Sandrina Kinet, Felix J Kim, Louise Swainson, Madakasira Lavanya, Jean-Luc Battini, Marc Sitbon
• Journal: Frontiers in bioscience : a journal and virtual library (Front Biosci) Vol. 9 Pg. 3218-41 (Sep 01 2004) ISSN: 1093-9946 [Print] United States
• PMID: 15353351 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Gene Products, env
• Glucose Transporter Type 1
• Glucose

Topics

• Animals
• Biological Transport
• Deltaretrovirus Infections (metabolism)
• Gene Products, env (metabolism, physiology)
• Glucose (metabolism)
• Glucose Transporter Type 1 (metabolism)
• Human T-lymphotropic virus 1 (metabolism)
• Human T-lymphotropic virus 2 (metabolism)
• Humans
• Hydrogen-Ion Concentration
• Leukemia, T-Cell (virology)
• Lymphocyte Activation
• Paraparesis, Tropical Spastic (virology)
• Protein Binding