[Amiodarone (cordarone) efficiency in atrial extrasystole].

Abstract

AIM:

To assess antiarrhythmic amiodarone efficacy of suppressing atrial extrasystoles resistant to other antiarrhythmic modalities.

MATERIAL AND METHODS:

The antiarrhythmic effect of amiodarone was studied in 70 patients (38 males, 32 females, mean age 49.6 +/- 1.7 years, mean duration of arrhythmia 4.9 +/- 1.5 years). The loading oral dose of amiodarone was 600-1200 mg/day for 10 days, mean maintenance dose--1656.25 mg a week, mean duration of treatment--27.5 +/- 3.2 months. The response to amiodarone was estimated by repeated 24-h Holter monitoring.

RESULTS:

A complete response was observed in 78.5% patients in loading and in 65.7% patients in maintenance therapy. A partial antiarrhythmic response was seen in 8.57 and 16.41% patients, respectively.

CONCLUSION:

Amiodarone is a basic drug against ventricular arrhythmia. Its effectiveness in suppression of atrial extrasystole is weaker but also appropriate.

• Authors: D I Reĭngardene, A P Azaravichene
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 76 Issue 6 Pg. 87-9 ( 2004) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' amiodarona (kordarona) pri predserdnoĭ ékstrasistolii.
• PMID: 15332585 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Amiodarone

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Amiodarone (administration & dosage, therapeutic use)
• Anti-Arrhythmia Agents (administration & dosage, therapeutic use)
• Atrial Premature Complexes (drug therapy, physiopathology)
• Depression, Chemical
• Electrocardiography, Ambulatory
• Female
• Humans
• Male
• Middle Aged
• Myocardial Contraction (drug effects)
• Time Factors
• Treatment Outcome