Growth hormone deficiency in Costello syndrome.

Abstract

We report on three patients with Costello syndrome and isolated growth hormone (GH) deficiency treated with biosynthetic GH. To our knowledge, these are the only patients with Costello syndrome who have been successfully treated for GH deficiency. We review the pathophysiology of Costello syndrome and highlight the recent recommendations of tumor screening and cardiac surveillance in this population, of particular relevance to those receiving GH therapy.

• Authors: Robert I Stein, Laurent Legault, Denis Daneman, Rosanna Weksberg, Jill Hamilton
• Journal: American journal of medical genetics. Part A (Am J Med Genet A) Vol. 129A Issue 2 Pg. 166-70 (Aug 30 2004) ISSN: 1552-4825 [Print] United States
• PMID: 15316968 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2004 Wiley-Liss, Inc.

Chemical References

• Growth Hormone

Topics

• Abnormalities, Multiple
• Age Factors
• Child
• Female
• Growth (drug effects)
• Growth Disorders (congenital, drug therapy, physiopathology)
• Growth Hormone (deficiency, therapeutic use)
• Humans
• Male
• Syndrome