Indinavir increases glucose production in healthy HIV-negative men.

Abstract

In the absence of HIV infection, changes in adipose tissue and lipid levels, HIV protease inhibitor therapy increases fasting glucose levels,suggestive of hepatic insulin resistance. After 4 weeks of indinavir treatment in nine HIV-negative healthy men, fasting glucose production and glycogenolysis were significantly increased. During the euglycemic hyperinsulinemic clamp, indinavir blunted the ability of insulin to suppress glucose production. Therefore, indinavir worsens hepatic insulin sensitivity, increasing endogenous glucose production.

• Authors: Jean-Marc Schwarz, Grace A Lee, Seongsoo Park, Mustafa A Noor, Jeongae Lee, Michael Wen, Joan C Lo, Kathleen Mulligan, Morris Schambelan, Carl Grunfeld
• Journal: AIDS (London, England) (AIDS) Vol. 18 Issue 13 Pg. 1852-4 (Sep 03 2004) ISSN: 0269-9370 [Print] England
• PMID: 15316349 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Glucose
• HIV Protease Inhibitors
• Insulin
• Indinavir

Topics

• Blood Glucose (metabolism)
• Body Composition
• Fasting (blood)
• HIV Protease Inhibitors (pharmacology)
• Humans
• Indinavir (pharmacology)
• Insulin (metabolism)
• Male