Evaluation of treatment for gastro-oesophageal reflux disease with a proton pump inhibitor, and relationship between gastro-oesophageal reflux disease and Helicobacter pylori infection in Japan.

Abstract

BACKGROUND:

Effective therapy for gastro-oesophageal reflux disease (GERD) is associated with improvement in health-related quality of life. It remains unclear whether Helicobacter pylori infection protects against GERD.

AIM:

We evaluated the relationship between GERD and H. pylori, and whether the health-related quality of life score improved after medical treatment.

METHODS:

We enrolled 151 outpatients with upper abdominal symptoms; 81 patients received omeprazole 20 mg/day for 2 weeks. Health-related quality of life was assessed using the Gastrointestinal Symptom Rating Scale (GSRS) and the Psychological General Well-Being (PGWB) index. H. pylori infection was diagnosed by serum antibody or endoscopy and the relationship between GERD and H. pylori was evaluated.

RESULTS:

In GERD patients, the mean GSRS score improved from 2.20 to 1.67 following treatment (P < 0.01). The mean GSRS reflux symptom score improved from 2.96 to 1.67 (P < 0.01). The mean PGWB score improved from 96.36 to 107.34 (P < 0.01). All scores in GERD patients significantly improved compared with non-GERD patients. The H. pylori-positive ratio was 66.15% in GERD patients and 65.21% in non-GERD patients (P = 0.94).

CONCLUSIONS:

Health-related quality of life is useful for evaluation of proton pump inhibitor treatment in GERD. The presence of H. pylori was not associated with the prevalence of GERD.

• Authors: A Muramatsu, T Azuma, T Okajima, M Ohtani, M Dojo, Y Yamazaki, M Kuriyama
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 20 Suppl 1 Pg. 102-6 (Jul 2004) ISSN: 0269-2813 [Print] England
• PMID: 15298614 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• Proton Pump Inhibitors
• Omeprazole

Topics

• Anti-Ulcer Agents (therapeutic use)
• Female
• Gastroesophageal Reflux (drug therapy, microbiology)
• Helicobacter Infections (complications, drug therapy)
• Helicobacter pylori
• Humans
• Male
• Middle Aged
• Omeprazole (therapeutic use)
• Proton Pump Inhibitors
• Quality of Life
• Surveys and Questionnaires
• Treatment Outcome