Floxuridine-containing regimens in the treatment of gestational trophoblastic tumor.

Abstract

OBJECTIVE:

To analyze the efficacy of floxuridine (FUDR)-containing regimens in the treatment of gestational trophoblastic tumor (GTT).

STUDY DESIGN:

Seventy-four patients with GTT, 47 with invasive mole and 27 with choriocarcinoma were treated with FUDR-containing regimens. Clinical staging of the disease was: 33 cases of stage I, 3 cases of stage II, 31 cases of stage IIIa, 6 cases of stage IIIb and 1 case of stage IV.

RESULTS:

The complete response rate of FUDR-containing regimens in the treatment of GTT was 91.9% (68 of 74 cases). Six patients, of whom 3 showed signs of drug resistance and 3 showed myelosuppression, had their regimens changed to non-FUDR-containing regimens, and all achieved a complete response. All 7 patients with advanced disease (>IIIb) achieved a complete response. The major adverse event with FUDR-containing regimens was myelosuppression and gastrointestinal toxicity: third- and fourth-degree neutropenia in 26% and thrombocytopenia in 6.2%, third-degree vomiting in 57.1% and third-degree diarrhea in 4.3%.

CONCLUSION:

FUDR-containing regimens are efficient for the treatment of GTT even for patients with advanced or drug-resistant disease.

• Authors: Xirun Wan, Xiuyu Yang, Yang Xiang, Yu Wu, Yanmei Yang, Shujie Ying, Jie Li
• Journal: The Journal of reproductive medicine (J Reprod Med) Vol. 49 Issue 6 Pg. 453-6 (Jun 2004) ISSN: 0024-7758 [Print] United States
• PMID: 15283053 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Floxuridine

Topics

• Antimetabolites, Antineoplastic (administration & dosage, adverse effects, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Choriocarcinoma (drug therapy, pathology)
• Female
• Floxuridine (administration & dosage, adverse effects, therapeutic use)
• Humans
• Hydatidiform Mole (drug therapy, pathology)
• Infusions, Intravenous
• Neoplasm Staging
• Pregnancy
• Treatment Outcome
• Uterine Neoplasms (drug therapy, pathology)