[Clinical courses of acute and chronic neuroborreliosis following treatment with ceftriaxone].

Abstract

Between 1990 and 2000, a total of 101 patients with acute (n=86) or chronic (n=15) neuroborreliosis (proven by clinical data, pleocytosis in the CSF, and elevated Borrelia burgdorferi-specific antibody indices) were treated with 2 g of ceftriaxone per day for either 2 or 3 weeks. The patients were reexamined clinically and serologically after 3, 6, and 12 months. Six (12) months after the antibiotic treatment, about 93% (95%) of the patients with acute neuroborreliosis and 20% (66%) of the patients with chronic neuroborreliosis were cured. One year after treatment, four patients with acute neuroborreliosis still suffered from facial palsy and five with chronic neuroborreliosis still had moderate spastic ataxic gait disturbance. The prognosis of facial palsy in neuroborreliosis is quite similar to that in idiopathic facial palsy, while that in chronic neuroborreliosis largely depends on the time elapsed before diagnosis.

• Authors: R Kaiser
• Journal: Der Nervenarzt (Nervenarzt) Vol. 75 Issue 6 Pg. 553-7 (Jun 2004) ISSN: 0028-2804 [Print] Germany
• Vernacular Title: Verlauf der akuten und chronischen Neuroborreliose nach Behandlung mit Ceftriaxon.
• PMID: 15257378 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Ceftriaxone

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Borrelia burgdorferi
• Ceftriaxone (therapeutic use)
• Child
• Chronic Disease
• Disease Progression
• Facial Paralysis (drug therapy, etiology)
• Female
• Follow-Up Studies
• Gait Disorders, Neurologic (drug therapy, etiology)
• Humans
• Lyme Neuroborreliosis (complications, drug therapy)
• Male
• Middle Aged
• Treatment Outcome