Abstract | BACKGROUND AND OBJECTIVE: PATIENTS AND METHOD: The study group included 77 ER and 47 ER/PgR breast carcinomas. Both ER and PgR were determined using EIAS from Abbott (USA). RESULTS: In ER tumors, one the most important finding was the high concentration (p = 0.001) and percentage of positives ( > 50 pmol/mg prot.; 24/41 vs 7/36; p < 0.01) of cathepsin D observed in N+ vs N- tumors. In ER/PgR negative tumors, lymph node involvement was associated with a same behavior of this proteinase (p = 0.021; 17/31 vs 2/16; p = 0.006) exclusively. CONCLUSIONS:
|
Authors | Alvaro Ruibal, José Ignacio Arias |
Journal | Medicina clinica
(Med Clin (Barc))
Vol. 123
Issue 2
Pg. 50-2
(Jun 12 2004)
ISSN: 0025-7753 [Print] Spain |
Vernacular Title | Invasión de los ganglios axilares en el carcinoma mamario con receptores hormonales negativos. |
PMID | 15225483
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Biomarkers
- Receptors, Estrogen
- Receptors, Progesterone
- Cathepsin D
|
Topics |
- Adult
- Aged
- Axilla
- Biomarkers
(analysis)
- Breast Neoplasms
(metabolism, pathology)
- Carcinoma, Ductal, Breast
(metabolism, secondary)
- Cathepsin D
(metabolism)
- Female
- Humans
- Lymphatic Metastasis
- Middle Aged
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
|