Abstract | BACKGROUND:
Essential hypertension affects more than 25% of the world's population. Genetic, physiologic, and epidemiologic studies provide clues to its origins, but a clear understanding has been elusive. Recent experimental and clinical studies have implicated uric acid in the onset of essential hypertension. METHODS: In a retrospective chart review, we identified 95 children with confirmed, new onset hypertension, and evaluated the cause of hypertension and parental history of hypertension, birth weight, and serum uric acid. In an open-label, cross-over trial we treated 5 children with confirmed essential hypertension with allopurinol as single treatment agent, and screened for change in blood pressure by casual and ambulatory methods. In tissue culture experiments, we evaluated the effect of uric acid on glomerular endothelial cell function. RESULTS: CONCLUSION:
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Authors | Daniel I Feig, Takahiko Nakagawa, S Ananth Karumanchi, William J Oliver, Duk-Hee Kang, Jennifer Finch, Richard J Johnson |
Journal | Kidney international
(Kidney Int)
Vol. 66
Issue 1
Pg. 281-7
(Jul 2004)
ISSN: 0085-2538 [Print] United States |
PMID | 15200435
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
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Topics |
- Animals
- Humans
- Hypertension
(etiology)
- Models, Biological
- Nephrons
(abnormalities)
- Uric Acid
(blood)
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