Abstract | BACKGROUND: METHODS: RESULTS: The prevalence of the metabolic syndrome increased with the severity of obesity and reached 50 percent in severely obese youngsters. Each half-unit increase in the body-mass index, converted to a z score, was associated with an increase in the risk of the metabolic syndrome among overweight and obese subjects (odds ratio, 1.55; 95 percent confidence interval, 1.16 to 2.08), as was each unit of increase in insulin resistance as assessed with the homeostatic model (odds ratio, 1.12; 95 percent confidence interval, 1.07 to 1.18 for each additional unit of insulin resistance). The prevalence of the metabolic syndrome increased significantly with increasing insulin resistance (P for trend, <0.001) after adjustment for race or ethnic group and the degree of obesity. C-reactive protein levels increased and adiponectin levels decreased with increasing obesity. CONCLUSIONS: The prevalence of the metabolic syndrome is high among obese children and adolescents, and it increases with worsening obesity. Biomarkers of an increased risk of adverse cardiovascular outcomes are already present in these youngsters.
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Authors | Ram Weiss, James Dziura, Tania S Burgert, William V Tamborlane, Sara E Taksali, Catherine W Yeckel, Karin Allen, Melinda Lopes, Mary Savoye, John Morrison, Robert S Sherwin, Sonia Caprio |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 350
Issue 23
Pg. 2362-74
(Jun 03 2004)
ISSN: 1533-4406 [Electronic] United States |
PMID | 15175438
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2004 Massachusetts Medical Society |
Chemical References |
- Adiponectin
- Intercellular Signaling Peptides and Proteins
- Interleukin-6
- Proteins
- C-Reactive Protein
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Topics |
- Adiponectin
- Adolescent
- Adult
- C-Reactive Protein
(analysis)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Glucose Tolerance Test
- Humans
- Insulin Resistance
(physiology)
- Intercellular Signaling Peptides and Proteins
- Interleukin-6
(blood)
- Logistic Models
- Male
- Metabolic Syndrome
(complications, epidemiology)
- Obesity
(blood, classification, complications)
- Prevalence
- Proteins
(analysis)
- Risk Factors
- Severity of Illness Index
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