Abstract |
To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. The X-ray structure showed our model as accurately predicted and useful for structure based drug design.
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Authors | Mayuko Takeda-Shitaka, Hiroyuki Nojima, Daisuke Takaya, Kazuhiko Kanou, Mitsuo Iwadate, Hideaki Umeyama |
Journal | Chemical & pharmaceutical bulletin
(Chem Pharm Bull (Tokyo))
Vol. 52
Issue 5
Pg. 643-5
(May 2004)
ISSN: 0009-2363 [Print] Japan |
PMID | 15133227
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Viral Proteins
- Endopeptidases
- 3C-like protease, SARS coronavirus
- Cysteine Endopeptidases
- Coronavirus 3C Proteases
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Topics |
- Antiviral Agents
(chemical synthesis)
- Coronavirus 3C Proteases
- Cysteine Endopeptidases
- Drug Design
- Drug Evaluation, Preclinical
(methods)
- Endopeptidases
(chemistry)
- Models, Molecular
- Severe acute respiratory syndrome-related coronavirus
(enzymology)
- Structural Homology, Protein
- Structure-Activity Relationship
- Viral Proteins
(chemistry)
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