Abstract |
Novel N- and O-acyl derivatives of threo-DL- phenylserine containing lipophilic long chain carboxylic or aryl(sulfon) amide groups were synthesized. Anti-inflammatory activity in carrageenin-induced paw edema model in rats was studied. Compound 10 had the most expressed anti-inflammatory effect over 24 h.
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Authors | N Dirvianskyte, L Leonaviciene, R Bradünaite, V Razumas, E Butkus |
Journal | Die Pharmazie
(Pharmazie)
Vol. 59
Issue 4
Pg. 321-3
(Apr 2004)
ISSN: 0031-7144 [Print] Germany |
PMID | 15125583
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Indicators and Reagents
- Serine
- Carrageenan
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(chemical synthesis, pharmacology)
- Carrageenan
- Edema
(chemically induced, drug therapy, pathology)
- Foot
(pathology)
- Indicators and Reagents
- Magnetic Resonance Spectroscopy
- Male
- Rats
- Rats, Wistar
- Serine
(analogs & derivatives, chemical synthesis, pharmacology)
- Spectrophotometry, Infrared
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