Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS:
Survivin was expressed in 34 tumors (55%) and did not correlate with ALK. A significant association between survivin expression and STAT3 activation was observed (P =.007, Fisher's exact test). For the ALK-positive group, the 5-year failure-free survival (FFS) was 34% for patients with survivin-positive ALCL compared with 100% for patients with survivin-negative ALCL (P =.009, log-rank test). For the ALK-negative group, the 5-year FFS was 46% for patients with survivin-positive tumors compared with 89% for patients with survivin-negative tumors (P =.03, log-rank test). Overall survival was similarly worse for patients with survivin-positive tumors in both the ALK-positive and ALK-negative groups. Furthermore, multivariate analysis confirmed the independent prognostic value of survivin expression, along with age older than 60 years and Ann Arbor stage III or IV. CONCLUSION:
Survivin is expressed in approximately half of ALCL tumors and independently predicts unfavorable clinical outcome. Modulation of survivin expression or function may provide a novel target for experimental therapy in patients with ALCL.
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Authors | Ellen J Schlette, L Jeffrey Medeiros, Andre Goy, Raymond Lai, George Z Rassidakis |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 22
Issue 9
Pg. 1682-8
(May 01 2004)
ISSN: 0732-183X [Print] United States |
PMID | 15117990
(Publication Type: Journal Article)
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Chemical References |
- Acute-Phase Proteins
- BIRC5 protein, human
- DNA-Binding Proteins
- Inhibitor of Apoptosis Proteins
- Microtubule-Associated Proteins
- Neoplasm Proteins
- STAT3 Transcription Factor
- STAT3 protein, human
- Survivin
- Trans-Activators
- ALK protein, human
- Anaplastic Lymphoma Kinase
- Protein-Tyrosine Kinases
- Receptor Protein-Tyrosine Kinases
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Topics |
- Acute-Phase Proteins
- Adult
- Age Factors
- Anaplastic Lymphoma Kinase
- Apoptosis
- DNA-Binding Proteins
(analysis, biosynthesis)
- Female
- Humans
- Inhibitor of Apoptosis Proteins
- Lymphoma, Large B-Cell, Diffuse
(genetics, pathology)
- Male
- Microtubule-Associated Proteins
(biosynthesis)
- Multivariate Analysis
- Neoplasm Proteins
- Neoplasm Staging
- Predictive Value of Tests
- Prognosis
- Protein-Tyrosine Kinases
(analysis, biosynthesis)
- Receptor Protein-Tyrosine Kinases
- STAT3 Transcription Factor
- Signal Transduction
- Survival Analysis
- Survivin
- Trans-Activators
(analysis, biosynthesis)
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