Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids.
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| Abstract |
The multidrug resistance (MDR) proteins that belong to the ATP-binding casette superfamily are present in a majority of human tumors and are an important final cause of therapeutic failure. Therefore, compounds which inhibit the function of the MDR-efflux proteins may improve the cytotoxic action of anticancer chemotherapy. The effects of carotenoids were studied on the activity of the MDR-1 gene-encoded efflux pump system. The carotenoids, isolated from paprika and other vegetables, were tested on the rhodamine 123 accumulation of human MDR-1 gene-transfected L1210 mouse lymphoma cells and human breast cancer cells MDA-MB-231 (HTB-26). Capsanthin and capsorubin enhanced the rhodamine 123 accumulation 30-fold relative to nontreated lymphoma cells. Lycopene, lutein, antheraxanthin and violaxanthin had moderate effects, while alfa- and beta-carotene had no effect on the reversal of MDR in the tumor cells. Apoptosis was induced in human MDR1 transfected mouse lymphoma cells and human breast cancer MDA-MB-231 (HTB-26) cell lines in the presence of lycopene, zeaxanthin and capsanthin. The data suggest the potential of carotenoids as possible resistance modifiers in cancer chemotherapy.
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| Authors | Joseph Molnár, Nóra Gyémánt, Ilona Mucsi, Annamária Molnár, Margaret Szabó, Tamás Körtvélyesi, András Varga, Péter Molnár, Gyula Tóth |
| Journal | In vivo (Athens, Greece) (In Vivo) 2004 Mar-Apr Vol. 18 Issue 2 Pg. 237-44 ISSN: 0258-851X [Print] Greece |
| PMID | 15113052 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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