Allochronic overlapping malignancies after renal transplantation in a patient with p53 gene mutation: report of a case.

Abstract	We report a rare case of the development of various tumors over a 16-year period after renal transplantation. A 56-year-old woman underwent renal transplantation using a US kidney. Immunosuppressive treatment consisted of a triple regimen of methylprednisolone, azathioprine, and mizoribine. Left breast cancer was diagnosed 9 years after the renal transplantation, then colon cancers and meningeal epidermal meningioma were diagnosed, 10 years and 12 years post-transplant, respectively. During the investigations for the breast and colon cancers, a p53 gene mutation was detected. A deterioration of renal function was found 16 years after the transplant and graft biopsy confirmed chronic rejection. We suggest that the effects of the immunosuppressive drugs combined with the p53 gene abnormality accelerated tumor development in this patient.
Authors	Teruhiko Kitayama, Seiji Marubayashi, Keisuke Hayamizu, Hirotaka Tashiro, Hideki Ohdan, Satoshi Ikeda, Tatsuya Okimoto, Masazumi Okajima, Tuyoshi Kataoka, Keizo Sugino, Toshimasa Asahara, Yasuhiko Fukuda, Kiyohiko Dohi
Journal	Surgery today (Surg Today) Vol. 34 Issue 5 Pg. 473-6 ( 2004) ISSN: 0941-1291 [Print] Japan
PMID	15108094 (Publication Type: Case Reports, Journal Article, Review)
Chemical References	Immunosuppressive Agents Ribonucleosides mizoribine Azathioprine Methylprednisolone
Topics	Azathioprine (administration & dosage) Breast Neoplasms (etiology, genetics, surgery) Carcinoma, Ductal, Breast (etiology, genetics) Colonic Neoplasms (etiology, genetics, surgery) Colonic Polyps (etiology, surgery) Drug Therapy, Combination Female Genes, p53 Graft Rejection Hemangioma (pathology) Humans Immunosuppressive Agents (administration & dosage) Kidney Transplantation (adverse effects) Liver Neoplasms (secondary) Methylprednisolone (administration & dosage) Middle Aged Mutation Neoplasms, Multiple Primary Postoperative Complications Ribonucleosides (administration & dosage)

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