Transitional cell metaplasia and ectopic prostatic tissue in the uterine cervix and vagina in a patient with adrenogenital syndrome: report of a case suggesting a possible role of androgen in the histogenesis.

Abstract

A case of extensive transitional cell metaplasia (TCM) and ectopic prostatic tissue was encountered in the uterine cervix and vagina of a 23-year-old woman with the adrenogenital syndrome. A previously described case of ectopic prostatic tissue in the cervix in a patient with female pseudohermaphroditism and our case suggest that prolonged androgen stimulation plays a role in the development of prostatic tissue. Similarly, the occurrence of TCM in the perimenopausal and postmenopausal periods when the ovaries secrete androgens, in female transsexuals treated with androgens, and in our patient with high endogenous androgen levels suggest that androgen has a major role in the histogenesis of TCM. Significantly decreased Ki-67 immunopositivity in TCM compared with the normal cervical mucosa of women in the reproductive age indicates that TCM is a mild form of epithelial atrophy, presumably caused by the neutralizing effect of androgens.

• Authors: Kyu-Rae Kim, Kyoung-Hee Park, Jung-Won Kim, Kyoung-Ja Cho, Jae Y Ro
• Journal: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (Int J Gynecol Pathol) Vol. 23 Issue 2 Pg. 182-7 (Apr 2004) ISSN: 0277-1691 [Print] United States
• PMID: 15084849 (Publication Type: Case Reports, Journal Article)

Chemical References

• Androgens
• Ki-67 Antigen

Topics

• Adrenal Hyperplasia, Congenital (blood, complications, pathology)
• Adult
• Androgens (blood, physiology)
• Choristoma
• Female
• Humans
• Ki-67 Antigen (biosynthesis)
• Male
• Metaplasia (etiology, pathology)
• Prostate
• Uterine Diseases (etiology, pathology)
• Vaginal Diseases (etiology, pathology)