Abstract | OBJECTIVE: Arterial stiffness is an emerging major risk factor for cardiovascular morbidity and mortality. The aim of the present study was to assess if coronary artery plaque load correlates with non-invasive measures of arterial stiffness. DESIGN: Prospective investigational study. SETTING: Tertiary university hospital centre. PATIENTS: Patients undergoing elective diagnostic coronary angiography. INTERVENTIONS AND MAIN OUTCOME MEASURES: Coronary artery plaque burden was assessed using a 30 MHz intravascular ultrasound catheter during an automated pullback. Proximal coronary artery plaque volume was determined using a validated edge-detection algorithm following three-dimensional computerized reconstruction. Central arterial stiffness was assessed in each patient using applanation tonometry to radial, carotid and femoral pulses, with derivation of aortic pressure augmentation and pulse wave velocity using pulse wave analysis. RESULTS: In 35 patients (61 +/- 2 years), proximal coronary arterial plaque volume was 5.9 +/- 0.6 mm3/mm of vessel. Plaque volume correlated positively with carotid-radial pulse wave velocity (r = 0.47, P = 0.008) and appeared to correlate with carotid-femoral pulse wave velocity (r = 0.34, P = 0.07). Aortic augmentation (r = 0.24, P = 0.16), augmentation index (r = 0.3, P = 0.08), and pulse pressure (r = 0.22, P = 0.2) did not correlate significantly with proximal coronary artery plaque volume. CONCLUSIONS:
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Authors | Andrew L McLeod, Neal G Uren, Ian B Wilkinson, David J Webb, Simon R J Maxwell, David B Northridge, David E Newby |
Journal | Journal of hypertension
(J Hypertens)
Vol. 22
Issue 2
Pg. 363-8
(Feb 2004)
ISSN: 0263-6352 [Print] Netherlands |
PMID | 15076195
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Algorithms
- Coronary Disease
(diagnostic imaging, physiopathology)
- Coronary Vessels
(diagnostic imaging, physiopathology)
- Female
- Femoral Artery
(physiopathology)
- Humans
- Image Processing, Computer-Assisted
- Imaging, Three-Dimensional
- Male
- Manometry
- Middle Aged
- Prospective Studies
- Pulse
- Radial Artery
(physiopathology)
- Ultrasonography, Interventional
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