Abstract |
Extensive studies have identified reliable markers of lymphatic endothelial cells, and mechanisms and molecules that regulate development and growth of the lymphatic vessels. Vascular endothelial growth factors ( VEGF)-C and VEGF-D, and their cognate receptor tyrosine kinase, VEGF receptor-3 (VEGFR-3), are critical regulators of lymphangiogenesis. By binding to its endothelial cell surface receptors VEGFR-1 and VEGFR-2, VEGF-A mediates vascular leakage, endothelial proliferation and migration. Angiopoietin-2 (Ang-2) is expressed at sites of blood vessel remodeling and invasion, and factors that induce angiogenesis in vivo, such as VEGF-A, upregulate Ang-2 in endothelial cells. In this review, we summarize the literature concerning the crosstalk between angiogenesis and lymphangiogenesis in tumor progression, that is, involvement of VEGF-C, VEGF-D and VEGFR-3 in angiogenesis, and the role played by VEGF-A and Ang-2 in lymphangiogenesis, respectively.
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Authors | C Scavelli, A Vacca, G Di Pietro, F Dammacco, D Ribatti |
Journal | Leukemia
(Leukemia)
Vol. 18
Issue 6
Pg. 1054-8
(Jun 2004)
ISSN: 0887-6924 [Print] England |
PMID | 15057248
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Vascular Endothelial Growth Factors
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Topics |
- Humans
- Lymphangiogenesis
(physiology)
- Lymphatic Metastasis
(physiopathology)
- Neovascularization, Pathologic
(pathology, physiopathology)
- Vascular Endothelial Growth Factors
(physiology)
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