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Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting.

Abstract
With the use of homologous recombination in embryonic stem cells, two new strains of mice lacking surface CD4 or CD8 expression have been generated. It is hoped that they will be useful mouse strains for the study of autoimmune diseases, tissue transplantation rejections and tumour rejections.
AuthorsT W Mak, A Rahemtulla, M Schilham, D R Koh, W P Fung-Leung
JournalJournal of autoimmunity (J Autoimmun) Vol. 5 Suppl A Pg. 55-9 (Apr 1992) ISSN: 0896-8411 [Print] England
PMID1503636 (Publication Type: Journal Article)
Chemical References
  • CD4 Antigens
  • CD8 Antigens
Topics
  • Animals
  • CD4 Antigens
  • CD8 Antigens
  • Genetic Engineering
  • Mice
  • Mice, Mutant Strains (immunology)
  • Recombination, Genetic
  • T-Lymphocytes (immunology)
  • Transfection

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