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Antisense protein kinase A RI alpha-induced tumor reversion: portrait of a microarray.

Abstract
Antisense oligonucleotides can selectively block disease-causing genes due to the specificity of the Watson-Crick base-pairing mechanism of action. A genome-wide view of antisense technology is illustrated via protein kinase A RI alpha antisense. Complementary DNA microarray analysis of the RI alpha antisense-induced expression profile shows the up- and down-regulation of clusters of coordinately expressed genes that define the molecular portrait of a reverted tumor cell phenotype. This global view broadens the horizons of antisense technology; it advances the promise of antisense beyond a single target gene to the whole cell and the whole organism. Along with recent rapid advances in oligonucleotide technologies-including new chemical and biological understanding of more sophisticated nucleic acid drugs-oligonucleotide-based gene silencing offers not only an exquisitely specific genetic tool for exploring basic science but also an exciting possibility for treating and preventing cancer and other diseases.
AuthorsYoon S Cho-Chung
JournalBiochimica et biophysica acta (Biochim Biophys Acta) Vol. 1697 Issue 1-2 Pg. 71-9 (Mar 11 2004) ISSN: 0006-3002 [Print] Netherlands
PMID15023351 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Antineoplastic Agents
  • Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
  • DNA, Complementary
  • Oligonucleotides, Antisense
  • PRKAR1A protein, human
  • Cyclic AMP-Dependent Protein Kinases
Topics
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Clinical Trials as Topic
  • Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
  • Cyclic AMP-Dependent Protein Kinases (antagonists & inhibitors, genetics)
  • DNA, Complementary (analysis)
  • Down-Regulation
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasms (drug therapy, enzymology, genetics, pathology)
  • Oligonucleotide Array Sequence Analysis
  • Oligonucleotides, Antisense (chemistry, genetics, pharmacology)
  • Phenotype
  • Up-Regulation

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