[Comparison of analgesics used during balanced anesthesia on the incidence of PONV].

Abstract

BACKGROUND:

When we make reference to the quality of anesthesia, we consider three points, early emergence, postoperative pain relief, and postoperative nausea and vomiting (PONV). Among these, PONV is comparatively neglected. Many analgesics used during anesthesia may cause PONV.

METHODS:

The incidence of PONV was assessed in 100 surgical patients who had received balanced anesthesia. Anesthesia was induced with propofol, ketamine, midazolam and buprenorphine (Group P), or butorphanol (Group T), and vecuronium was given to facilitate tracheal intubation. The patients received balanced anesthesia with infusion of propofol, ketamine, vecuronium, and either buprenorphine (Group P) or butorphanol (Group T), with nitrous oxide. PONV was recorded for 24 hours postoperatively.

RESULTS:

Incidences of nausea were 27.1% in Group P and 15.8% in Group T (NS). Incidences of vomiting were 12.5% in Group P and 5.3% in Group T (NS). However, a high incidence of PONV was found in female (42.2%) vs. male (6.2%) (P < 0.01) and in over 25 BMI group (34.5%) vs. under 25 BMI group (15.5%) (P < 0.05).

CONCLUSIONS:

The type of analgesics used during balanced anesthesia is not important for development of PONV, but patient's factors, such as gender and BMI, are more closely associated with PONV.

• Authors: Masahiko Onaka, Hiromitsu Yamamoto
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 53 Issue 2 Pg. 161-6 (Feb 2004) ISSN: 0021-4892 [Print] Japan
• PMID: 15011424 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Analgesics, Opioid
• Buprenorphine
• Butorphanol

Topics

• Aged
• Analgesics, Opioid
• Anesthesia (methods)
• Body Mass Index
• Buprenorphine
• Butorphanol
• Female
• Humans
• Incidence
• Male
• Middle Aged
• Postoperative Nausea and Vomiting (epidemiology)
• Sex Factors