Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: Patients with type 2 diabetes receiving metformin and/or sulfonylurea (n = 829) were evaluated in this national, multicenter, retrospective study. Medical records from 318 endocrinology practices in the USA were randomly selected and screened for study inclusion. Data related to patient demographics and laboratory data were extracted from medical records and analyzed for primary and secondary outcomes. MAIN OUTCOME MEASURES: RESULTS: With pioglitazone, TG levels declined by a mean of 51.5 mg/dl (P < 0.001), HDL-C levels rose by 3.3mg/dl (P < 0.001), and no change was seen in LDL-C or TChol. Treatment with change in TG levels and a 1.5mg/dl mean increase in HDL-C (P < 0.001). Furthermore, rosiglitazone therapy was associated with an 8 mg/dl mean increase in TChol (P < 0.001), and a 5.8 mg/dl mean increase in LDL-C (P < 0.001). Hemoglobin A1C levels were significantly reduced by approximately 1% within thiazolidinedione (TZD) cohorts (P < 0.001), but were not significantly different between study groups (P = 0.257). CONCLUSIONS: Results from this study suggest that pioglitazone has a more favorable effect on lipid profiles of patients with type 2 diabetes compared with rosiglitazone. In particular, differences were observed in TG and LDL-C levels. Both TZDs were equivalent at reducing hemoglobin A1C levels. These differences in lipid effects may have an impact on cardiovascular outcomes. The full clinical importance of these lipid alterations must be further assessed in prospective trials.
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Authors | Anne L Peters Harmel, David M Kendall, John B Buse, Patrick J Boyle, Albert Marchetti, Helen Lau |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 20
Issue 2
Pg. 215-23
( 2004)
ISSN: 0300-7995 [Print] England |
PMID | 15006017
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Blood Glucose
- Hypoglycemic Agents
- Lipids
- Sulfonylurea Compounds
- Thiazolidinediones
- Rosiglitazone
- Metformin
- Pioglitazone
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Topics |
- Adult
- Aged
- Anticholesteremic Agents
(pharmacology)
- Blood Glucose
(drug effects)
- Diabetes Mellitus, Type 2
(drug therapy)
- Drug Therapy, Combination
- Female
- Humans
- Hypoglycemic Agents
(administration & dosage, pharmacology)
- Lipids
(blood)
- Male
- Metformin
(administration & dosage)
- Middle Aged
- Pioglitazone
- Retrospective Studies
- Rosiglitazone
- Sulfonylurea Compounds
(administration & dosage)
- Thiazolidinediones
(administration & dosage, adverse effects, pharmacology)
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